Activation process of carbon molecules effectively forms fine networks of interlocking minuscule pores which increase the internal surface area of the resulting activated charcoal tremendously.
The resulting increase in surface area determines
How does Activated Charcoal works?
Activated charcoal adsorbs substances by physical forces and 'traps' these adsorbed substances in its fine network of interlocking pores.
Medicinal Use of Activated Charcoa
First Choice in Treatment of Acute Diarrhea
Why Norit Activated Charcoal?
Why Norit Activated Charcoal is Special?
The Only medicinal grade that conforms to US and European Pharmacopoeia Grade
Easy to swallow / No black teeth
Fast onset of action
Other therapeutic indications
A Finnish study has shown that the blood cholesterol levels of patients suffering from hyper-cholesterolaemia was reduced by 25% following the administration of activated carbon. The LDL-cholestrol level was reduced by at least 41% (The LDL = Low-Density Lipoprotein binds with newly made cholesterol. A high LDL level means a high blood cholesterol level).
The HDL level increased by 8% (The HDL = High Density Lipoprotein binds the cholesterol that is broken down in the body. A high HDL level means that the cholesterol level in the blood will be reduced). No significant side-effects were reported.
Some constituents of alcoholic drinks form toxic products in the gastro-intestinal tract and in the blood- stream. This is the origin of the hangover, which is preventable if activated carbon is taken as a prophylactic measure. Even after drinking, activated carbon will treat the symptoms of the hangover quickly, by rapid adsorption of the toxics produced. As mentioned above, alcohol itself is only slightly adsorbed by activated carbon.
The use of Activated Charcoal in the early part of the 20th century in USA in treatment of *meteorism* (a tendency to uncontrollable flatulence) without success and definite harm caused from its long term continued use has clearly without doubt led to its deletion from the US Pharmacopoeia before its reinstatement in the 1960's. By the 1960's, much more knowledge of activated charcoal is known that pharmacopoeia grade activated charcoal will not only adsorb toxins, but also vitamins, minerals, digestive enzymes, amino acids and other valuable nutrients from the gut.
For these same reasons, there has been over a hundred patents for use in weight control using Pharmacopoeia
Grade Activated Charcoal in the USA. (All brands of pharmacopoeia grade activated charcoal in the US have their raw material sourced from NORIT, USA)
Activated charcoal is obtained from vegetable matter by suitable carbonisation processes intended to confer a high adsorption power.
A black, light powder free from grittiness, practically insoluble in all usual solvents.
Solution S. To 2.0g in a conical flask with a ground-glass neck add 50ml of dilute hydrochloric acid R. Boil gently under a reflux condenser for 1 h, filter and wash the filter with dilute hydrochloric acid R. Evaporate the combined filtrate and washings to dryness on a water-bath, dissolve the residue in 0.1 M hydrochloric acid and dilute to 50.0ml with the same acid.
Acidity or alkalinity.
To 2.0g add 40ml of water R and boil for 5 min. Cool, restore to the original mass with carbon dioxide-free water R and filter. Reject the first 20ml of the filtrate. To 10ml of the filtrate add 0.25ml of bromothymol blue solution R1 and 0.25ml of 0.02 M sodium hydroxide. The solution is blue. Not more than 0.75ml of 0.02M hydrochloric acid is required to change the colour of the indicator to yellow.
To 1.0g add 25ml of dilute nitric acid R and boil for 5 min. Filter whilst hot through a sintcred-glass filter (10) and wash with 10ml of hot water R. Evaporate the combined filtrate and washings to dryness on a water-bath, add to the residue 1ml of hydrochloric acid R, evaporate to dryness again and dry the residue to constantmass at 100 °C to 105 °C. The residue weighs not more than 30mg (3 per cent).
Alkali-soluble coloured substances.
To 0.25g add 10ml of dilute sodium hydroxide solution R and boil for 1 min. Cool, filter and dilute the filtrate to 10ml with water R. The solution is not more intensely coloured than reference solution GY4 (2.2.2, Method II).
To 2.0g add 50ml of alcohol R and boil under a reflux condenser for 10 min. Filter immediately, cool, and dilute to 50ml with alcohol R. The filtrate is not more intensely coloured than reference solution Y6 or BY6 (2.2.2, Methold II). Evaporate 40ml of the filtrate to dryness and dry to constant mass at 100 °C to 105 °C. The residue weighs not more than 8 mg (0.5 per cent).
In an intermittent-extraction apparatus, treat 10.0g with 100ml of cyclohexane R1 for 1 h. Collect the liquid and dilute to 100ml with cyclohexane R1. Examine in ultraviolet light at 365 nm. The fluorescence of the solution is not more intense than that of a solution of 83µg of quinine R in 1000ml of 0.005 M sulphuric acid examined in the same manner.
To 1.0g in a conical flask add 5ml of hydrochloric acid R1 and 20ml of water R. Meat to boiling. The fumes released do not turn lead acetate paper R brown.
Not more than 25 ppm of Cu, determined by atomic absorption spectrometry (2.2.23, Method I).
Test solution. Use solution S.
Prepare the reference solutions using copper standard solution (0.1 per cent Cu) R and diluting with 0.1 M hydrochloric acid.
Measure the absorbance at 325.0 nm using a copper hollow-cathode lamp as source of radiation and an air-acetylene flame.
Not more than 10 ppm of Pb, determined by atomic absorption spectrometry (2.2.23, Method I).
Test solution. Use solution S.
Prepare the reference solutions using lead standard solution (l00ppm Pb) R and diluting with 0.1 M hydrochloric acid.
Measure the absorbance at 283.3 nm using a lead hollow-cathode lamp as source of radiation and an air-acetylene flame. Depending on the apparatus the line at 217.0 nm may be used.
Not more than 25 ppm of Zn, determined by atomic absorption spectrom-erty (2.2.23, Method I).
Test solution. Use solution S.
Prepare the reference solutions using zinc standard solution (100 ppm Zn) R and diluting with 0.1 M hydrochloric acid.
Measure the absorbance at 214.0 nm using a zinc hollow-cathode lamp as source of radiation and an air-acetylene flame.
Loss on drying. (2.2.32).
Not more than 15 per cent, determined on 1.00g by drying in an oven at 120 °C for 4 h.
Sulphated ash. (2.4.14).
Not more than 5.0 per cent, determined on 1.0g.
To 0.300g in a 100ml ground-glass-stoppered conical flask add 25.0ml of a freshly prepared solution of 0.5g of phenazone R in 50ml of water R. Shake throughly for 15 min. Filter and reject the first 5ml of filtrate. To 10.0ml of the filtrate add 1.0g of potassium bromide R and 20ml of dilute hydrochloric acid R. Using 0.1ml of methyl red solution R as indicator, titrate with 0.0167 M potassium bromate until the red colour is discharged. Titrate slowly (1 drop every 15 s) towards the end of the titration. Carry out a blank titration using 10.0ml of the phenazone solution.
Calculate the quantity of phenazone adsorbed per 100g of activated charcoal from the expression:
a = number of millilitres of 0.0167 M potassium brotnate used for the blanks,
b = number of millilitres of 0.0167 M potassium brotnate used for the test,
m = mass in grams of the substance to be examined.
Not less than 40g of phenazone is adsorbed per 100g of activated charcoal, calculated with reference to the dried substance.
Total viable aerobic count (2.6.12) not more than 103 micro-organisms per gram, determined by plate acoum.
Store in an airtight container.
Norit Carbomix is officially listed in MOH Drug
Formulary as: Charcoal, Activated 50g Granules [A07BA0I-000-F10-01-XX]
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